Originally developed in the fields of architecture and urban design, space syntax is a concept and method used to describe and analyze patterns of space at both the building and urban levels. In particular, space syntax helps us understand the role of spatial configuration within buildings and cities in people’s experiences and use of these spaces. It is now applied in a wide range of research areas, including transportation, crime pattern and space, wayfinding, disaster management, and air pollution. In this Forum, Dr. Baran will highlight several studies that have integrated space syntax measures and a range of qualitative and quantitative data in the realms of crime pattern analysis, urban legibility, neighborhood inertia, and physical activity.